History offers plenty of examples of female involvement in political violence, but a certain fascination and disbelief continue to surround female violent extremists because women are often still viewed as homemakers and mothers, surprising society by the number of young girls and women joining the Islamic State of Iraq and the Levant. This policy brief explores the drivers of radicalization to and engagement in violent extremism and the factors of disengagement and desistance among women and girls by examining cases of individuals that went through the United Kingdom’s Channel program. Channel cases were chosen for this analysis because it is one of the longest running (since 2007) and most documented early intervention programs developed specifically to prevent engagement with terrorism and violent extremism. It aims to enhance understanding of gender-sensitive interventions that address the specific needs of women and girls. Recommendations include the focus on mechanisms for women and men to claim their rights and have their grievances heard while ensuring accountability mechanisms are in place and the need to more effectively combine online and offline preventing and countering violent extremism actions.